Anti-CD235a IgG1 Antibody, Biotin-Labeled

CD235a, also known as Glycophorin A (GYPA), is a sialoglycoprotein and a major intrinsic membrane protein on the surface of human erythrocytes. CD235a plays an important role in the prevention of red cell aggregation in the circulatory system. The Glycophorin A gene contains some antigenic alleles of the MNS blood grouping system for which 40 known variants exist. Several of these antigenic variants have implications for pathogen interaction. For example, the Wright b antigen in the helical region of Glycophorin A acts as a receptor for the malaria parasitePlasmodium falciparum. Other variations such as the Mur phenotype cause hemolytic transfusion reaction (HTR) and hemolytic disease in the newborn fetus (HDFN) . CD235a is one of the most abundant integral proteins of the red cell membrane, and its genetic sequence varies within a population; therefore, it may also support applications in forensic science.

This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation is confirmed to be ≥90%.For more information on enzymatic biotinylation, please see ourTech Note.