HDAC4, GST-Tag Recombinant

HDAC4, or histone deacetylate 4, is a Class II member of the histone deacetylase family which is involved in lysine deacetylation. Lysine acetylation/deacetylation is a dynamic process involved in the regulation of a variety of cellular functions, similarly to phosphorylation/dephosphorylation. It interacts with MEF2C (myocyte-specific enhancer factor 2c) and MEF2D and this interaction allows regulation of gene expression. It also functions in multimeric protein complexes. HDAC4 is regulated by phosphorylation, SUMOylation and proteolytic cleavage, which influence the protein localization in the cell. It is involved in bone and muscle development, and vision. Dysfunction of HDAC4 seems to link to cancer in a context-dependent mode, but the mechanisms behind it are still unclear. It has been linked to multiple myeloma (MM) and acute myeloid leukemia (AML) . The development of new inhibitors specifically targeting HDAC4, in a disease-specific context, and a better understanding of its modes of action may open newer avenues of HDAC4-linked diseases.