Azoxystrobin

Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis[1][2][3][4].

Product Specifications

CAS Number

[131860-33-8]

UNSPSC

12352005

Hazard Statement

H331, H410

Target

Apoptosis; Bacterial; Fungal; Phosphatase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/azoxystrobin.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CO/C=C(C(OC)=O)\C(C=CC=C1)=C1OC2=NC=NC(OC3=C(C#N)C=CC=C3)=C2

Molecular Formula

C22H17N3O5

Molecular Weight

403.39

Precautions

H331, H410

References & Citations

[1]Enock Mpofu, et al. Azoxystrobin amine: A novel azoxystrobin degradation product from Bacillus licheniformis strain TAB7. Chemosphere. 2021 Jun;273:129663. |[2]Bertelsen, J.R, et al. Fungicidal effects of azoxystrobin and epoxiconazole on phyllosphere fungi, senescence and yield of winter wheat. Plant Pathology, 50: 190-205.|[3]Zhang Q, et al. Oral azoxystrobin driving the dynamic change in resistome by disturbing the stability of the gut microbiota of Enchytraeus crypticus. J Hazard Mater. 2022 Feb 5;423 (Pt B) :127252.|[4]Wang X, et al. Fungicide azoxystrobin induced changes on the soil microbiome[J]. Applied Soil Ecology, 2020, 145: 103343.