BAFF, His-Avi-Tag Recombinant
Recombinant human BAFF (B-cell-activating factor, also known as TNFSF13B, Tumor necrosis factor ligand superfamily member 13B), encompassing amino acids 134-285. This construct contains an N-terminal His-tag (6xHis) followed by an Avi-Tag™. The recombinant protein was affinity purified.
Product Specifications
Background
B-cell activating factor (BAFF) is a cytokine regulating B cell development, survival, and antibody production. It is a key player in the immune response and has implications in autoimmune diseases. It is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF normally maintains immune balance, and overproduction of BAFF leads to various auto-immune diseases. It is, therefore, a therapeutic target. Drugs that inhibit BAFF, such as belimumab, have been approved for the treatment of certain autoimmune disorders.
UniProt
Q9Y275
Tag
N-terminal His-Avi-Tag
Applications
Useful for binding studies and screening inhibitors of ligand binding to its receptor.
Purity
≥ 90%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at –80°C
Calculated Molecular Weight
20 kDa + glycans
Formulation
8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Glycosylation
This protein runs at a higher MW by SDS-PAGE due to glycosylation.
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