PI3Kδ (p110δ/p85α) Assay Kit
The PI3Kδ (p110δ/p85α) Assay Kit is designed to measure PI3Kδ (PI3K-delta) activity for screening and profiling applications, using ADP-Glo® Kinase Assay as a detection reagent.Need us to run inhibitor screens or profile your compounds against PI3Kδ (p110δ/p85α) ? Check out ourKinase Screening Services.
Product Specifications
Background
PI3Ks (Phosphatidylinositol 3-kinases) are lipid kinases that phosphorylate PIP2 (phosphatidylinositol 4,5-bisphosphate) to produce PIP3 (phosphatidylinositol 3,4,5-trisphosphate), which plays important roles in fundamental cellular activities such as cell growth, survival, migration, and metabolism. In human cancers, gain-of-function mutations of PI3Ks are found frequently, suggesting that PI3Ks are closely involved in tumorigenesis and that PI3K targeting inhibitors may be promising anticancer drug candidates.
UniProt
P110δ: O00329; p85α: P27986
Format
CatalogNumberReagentAmountStorage40628PI3Kδ (p110δ/p85α) 15 µg-80°CAvoid multiplefreeze/thawcycles!793345x Kinase assay buffer1.5 ml-20°C79686ATP (500 μM) 100 µl-20°C40560PI3K lipid substrate (Packaged separately, Do Not Freeze!) 500 µl4°C7969696-well plate, white1Room Temp.
Shipping Conditions
-80°C
Storage Conditions
Up to 6 months when stored as recommended.
Contraindications
Avoid > 0.5% DMSO. Higher DMSO levels can significantly decrease the enzyme activity.
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