Human Recombinant PKM2

<strong>Human Recombinant PKM2 </strong>_x000D_ <strong>Catalog number:</strong> B2017029_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 58.9 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> CTHBP, Cytosolic Thyroid Hormone-binding Protein, OIP3, Opa-interacting Protein 3, Pyruvate Kinase Muscle 2, THBP1, Thyroid Hormone-binding Protein 1_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Dhanesha N, Patel RB, Doddapattar P, Ghatge M, Flora GD, Jain M, Thedens D, Olalde H, Kumskova M, Leira EC, Chauhan AK. PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke Blood. 2022 Feb 24;139(8):1234-1245._x000D_ 2: Magadum A, Singh N, Kurian AA, Munir I, Mehmood T, Brown K, Sharkar MTK, Chepurko E, Sassi Y, Oh JG, Lee P, Santos CXC, Gaziel-Sovran A, Zhang G, Cai CL, Kho C, Mayr M, Shah AM, Hajjar RJ, Zangi L. Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration Circulation. 2020 Apr 14;141(15):1249-1265._x000D_ 3: Yu S, Zang W, Qiu Y, Liao L, Zheng X. Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis Oncogene. 2022 Jan;41(1):46-56._x000D_ 4: Wang F, Wang K, Xu W, Zhao S, Ye D, Wang Y, Xu Y, Zhou L, Chu Y, Zhang C, Qin X, Yang P, Yu H. SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice Cell Rep. 2017 Jun 13;19(11):2331-2344._x000D_ 5: Huang Y, Chen Z, Lu T, Bi G, Li M, Liang J, Hu Z, Zheng Y, Yin J, Xi J, Lin Z, Zhan C, Jiang W, Wang Q, Tan L. HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer J Exp Clin Cancer Res. 2021 Dec 20;40(1):398._x000D_ 6: Zheng YW, Wang M, Xie JW, Chen R, Wang XT, He Y, Yang TC, Liu LL, Lin LR. Recombinant Treponema pallidum protein Tp47 promoted the phagocytosis of macrophages by activating NLRP3 inflammasome induced by PKM2-dependent glycolysis J Eur Acad Dermatol Venereol. 2023 Oct;37(10):2067-2079._x000D_ 7: Gehrig S, Macpherson JA, Driscoll PC, Symon A, Martin SR, MacRae JI, Kleinjung J, Fraternali F, Anastasiou D. An engineered photoswitchable mammalian pyruvate kinase FEBS J. 2017 Sep;284(18):2955-2980._x000D_ 8: Hamza A, Cho JY, Cap KC, Hossain AJ, Kim JG, Park JB. Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition Free Radic Biol Med. 2023 Nov 1;208:614-629._x000D_ 9: Chen Y, Han Z, Zhang L, Gao C, Wei J, Yang X, Han Y, Li Y, Zhang C, Wei Y, Dong J, Xun W, Sun W, Zhang T, Zhang H, Chen J, Yuan P. TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma J Transl Med. 2024 Jan 4;22(1):21._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31900225">10: Wang C, Jiang X, Li X, Song S, Meng Q, Wang L, Lu Y, Xin X, Pu H, Gui X, Li T, Lu D. Long noncoding RNA HULC accelerates the growth of human liver cancer stem cells by upregulating CyclinD1 through miR675-PKM2 pathway via autophagy Stem Cell Res Ther. 2020 Jan 3;11(1):8. </a>_x000D_ _x000D_ <strong>Products Related to Human Recombinant PKM2 can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>