SHP-2, His-Tag Recombinant
Human recombinant SHP-2 (Src homology domain 2 containing tyrosine phosphatase, also known as protein tyrosine phosphatase N11, PTPN11), full length encompassing amino acids 2-593 (end) . This construct contains an N-terminal His-tag (6xHis) . The recombinant protein was affinity purified and tested for activity.This product has beencited 2 times.
Product Specifications
Background
Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
UniProt
Q06124
Tag
N-terminal His-tag
Purity
≥ 80%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at –80°C.
Calculated Molecular Weight
70 kDa
Formulation
40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.
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