XIAP, Bir2-Bir3 Domains, His-Tag Recombinant
Recombinant human XIAP (x-linked inhibitor of apoptosis protein), encompassing amino acids 120-356, corresponding to the Bir2-Bir3 (baculovirus IAP repeat) domains. This construct contains an N-terminal His-tag (6xHis) . The protein was affinity purified.
Product Specifications
Background
The XIAP (X-linked inhibitor of apoptosis protein), also known as IAP3 (inhibitor of apoptosis protein 3) and BIRC4 (baculoviral IAP repeat-containing protein 4), is a member of the IAP family of proteins. XIAP directly regulates caspases and suppresses apoptotic cell death pathways. XIAP has three Bir (baculovirus IAP repeat) domains, involved in binding to caspases. Bir2 inhibits caspase 3 and 7, while Bir3 is involved in caspase 9 inhibition. An increased expression level of XIAP has been observed in many cancer types, such as prostate cancer. Dysfunction of XIAP has been linked to inflammatory bowel disease, cancer, neurodegenerative and autoimmunity disorders.
UniProt
P98170
Tag
N-terminal His-tag
Applications
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Purity
≥ 80%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at -80°C.
Calculated Molecular Weight
28 kDa
Formulation
40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, variable Imidazole, 20% glycerol, 3 mM DTT
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Mouse Monoclonal DOG1/TMEM16A Antibody (SPM580) [DyLight 488]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP2-34812G 0.1 mL
Mouse Monoclonal DOG1/TMEM16A Antibody (SPM580) [DyLight 488]
Sign In for Pricing
View Details 
