PD-1[Biotinylated]:PD-L1 Inhibitor Screening Assay Kit
The PD-L1 Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this signaling. The key to thisPD-1:PD-L1 Inhibitor Screening Assay Kitis the high sensitivity of detection of biotin-labeled PD-1 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, PD-L1 is coated on a 96-well plate. Next, PD-1 is incubated with PD-L1 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can then be measured using a chemiluminescence reader.Need us to run inhibitor screens or profile your compounds against PD-1[Biotinylated]: PD-L1? Check out ourImmunotherapy Biochemical Screening Services.This product has beencited 9 times.
Product Specifications
Background
Cell signaling through the PD-1 receptor upon binding the PD-L1 ligand attenuates immune responses and is exploited by both tumors and viruses.
UniProt
PD-1: Q15116; PD-L1: Q9NZQ7
Applications
This kit is most useful for screening for inhibitors of PD-L1.
Format
Shipping Conditions
-80°C
Storage Conditions
Notes
384-well format available upon request.Contact[email protected]
Contraindications
DMSO > 1%, strong acids or bases, ionic detergents, high salt.
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