Anti-PD-1 (S228P) Neutralizing Antibody
Humanized recombinant anti-PD-1 (IgG4) antibody with S228P mutation, expressed in HEK293 cells. This antibody has not been tested with other species.This product has beencited 1 time.
Product Specifications
Background
This antibody binds and blocks the activation of the PD-1 receptor. The antibody is humanized, containing a human IgG4 Fc region with an engineered hinge region mutation (S228P) designed to prevent the exchange of IgG4 molecules. This antibody is equivalent to Nivolumab, which has been approved by the FDA for the treatment of melanoma and metastatic squamous non-small cell lung cancer.
CAS Number
9007-83-4
UniProt
Q15116
Purification
Protein A affinity chromatography from HEK293 supernatants.
Purity
≥ 90%
Format
Aqueous buffer solution.
Shipping Conditions
-80°C
Storage Conditions
Stable for at least 12 months at -80°C.
Calculated Molecular Weight
Heavy Chain: 50 kDa, Light Chain: 25 kDa
Formulation
8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
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