Anti-CD20 Functional Antibody
Anti-CD20 Functional Antibody is a chimeric monoclonal antibody that recognizes human CD20. The antibody features the constant region of the human IgG1 isotype and the mouse variable region of rituximab (amino acids 142-184) . This antibody is cytotoxic to WIL2-S cells in the presence of the rabbit complement system. The recombinant antibody was affinity purified.
Product Specifications
Background
CD20 is present in the membrane of mature, normal, and abnormal B cells, but not in immature B cells. This expression pattern made it an attractive target for antibody-based lymphoma treatment as immature B cells will not be affected and can replenish the B cell population. Rituximab was the first anti-CD20 monoclonal antibody to reach the clinic, and since its commercialization it has led to a decrease in the number of deaths due to B cell malignancy.
CAS Number
9007-83-4
UniProt
P11836
Applications
Detection of CD20 and functional studies involving CD20 in biochemical and cellular assays.
Purity
≥ 90%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at -80°C.
Calculated Molecular Weight
Heavy Chain: 51 kDa; Light Chain: 25 kDa
Formulation
8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol
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