MYLIP/IDOL, His-FLAG-tag Recombinant
Human MYLIP, also known as Inducible Degrader of the LDL receptor (IDOL), GenBank Accession No. NM_013262, a.a. 2-445 (end), with N-terminal His-FLAG-tag, MW=51.7 kDa, expressed in a baculovirus expression system.
Product Specifications
Background
MYLIP is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Its activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibition of neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
UniProt
Q8WY64
Tag
N-terminal His-FLAG-tag
Applications
Useful for studying protein binding and screening small molecules for drug discovery.
Purity
≥ 89%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
> 6 months at -80°C
Calculated Molecular Weight
51.7 kDa
Formulation
40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 80 µg/ml FLAG peptide, and 20% glycerol.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
EK6812 48 Tests
Human Synaptotagmin-like protein 1 (SYTL1) ELISA Kit
Sign In for Pricing
View Details 