RbBP5, His-tag Recombinant
Human retinoblastoma binding protein 5 (RbBP5), GenBank Accession No. NM_005057, a.a. 2 – 538 (end) with N-terminal His-tag, MW= 60 kDa, expressed in anE. coliexpression system.
Product Specifications
Background
RbBP5 binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. In embryonic stem (ES) cells, RbBP5 plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3Lys4 methylation at key developmental loci, including that mediated by retinoic acid. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at Lys4 of histone H3.
UniProt
Q15291
Tag
N-terminal His-tag
Applications
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Purity
≥ 65%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
> 6 months at -80°C
Calculated Molecular Weight
60 kDa
Formulation
20 mM Tris-HCl, pH 7.4,300 mM NaCl, 10% glycerol, 1 mM TCEP, and 1 µM ZnCl2
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