Ash2L, His-tag Recombinant
Recombinant human full length Ash2L (Absent, small or homeotic-2 like protein), amino acids 2-534. This construct contains an N-terminal His-tag (6xHis) . This protein was affinity purified.
Product Specifications
Background
Ash2L (Absent, small or homeotic-like protein), is a subunit of histone H3K4 lysine methyltransferase complex, such as the MLL1 (mixed lineage leukemia 1) and MLL3 complex. It belongs to the trithorax family of proteins and regulates cell proliferation and cell fate. For instance, it is critical to regulate the transition from pluripotency to a differentiated cell via its effects on pluripotency genes. This protein has been linked to cancer, as it interacts with MYC and RAS (rat sarcoma virus), and it is overexpressed in several solid tumors and leukemia cell lines. Trying to understand the role of this protein and how to best use its properties to develop new therapeutics is an exciting and ongoing field of research.
UniProt
Q9UBL3
Tag
N-terminal His-tag
Applications
Useful for SDS-PAGE.
Purity
≥ 90%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at -80°C.
Calculated Molecular Weight
61 kDa
Formulation
40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20,20% glycerol, and variable imidazole
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