Ash2L, His-tag Recombinant

Recombinant human full length Ash2L (Absent, small or homeotic-2 like protein), amino acids 2-534. This construct contains an N-terminal His-tag (6xHis) . This protein was affinity purified.

Product Specifications

Background

Ash2L (Absent, small or homeotic-like protein), is a subunit of histone H3K4 lysine methyltransferase complex, such as the MLL1 (mixed lineage leukemia 1) and MLL3 complex. It belongs to the trithorax family of proteins and regulates cell proliferation and cell fate. For instance, it is critical to regulate the transition from pluripotency to a differentiated cell via its effects on pluripotency genes. This protein has been linked to cancer, as it interacts with MYC and RAS (rat sarcoma virus), and it is overexpressed in several solid tumors and leukemia cell lines. Trying to understand the role of this protein and how to best use its properties to develop new therapeutics is an exciting and ongoing field of research.

UniProt

Q9UBL3

Tag

N-terminal His-tag

Applications

Useful for SDS-PAGE.

Purity

≥ 90%

Format

Aqueous buffer solution

Shipping Conditions

-80°C

Storage Conditions

At least 6 months at -80°C.

Calculated Molecular Weight

61 kDa

Formulation

40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20,20% glycerol, and variable imidazole