Indimitecan (hydrochloride)

Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activities[1].

Product Specifications

CAS Number

[915303-04-7]

Product Name Alternative

LMP776 (hydrochloride)

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/indimitecan-hydrochloride.html

Smiles

O=C1C2=C(C3=C1C4=CC(OC)=C(C=C4C(N3CCCN5C=NC=C5)=O)OC)C=C6OCOC6=C2.Cl

Molecular Formula

C25H22ClN3O6

Molecular Weight

495.91

References & Citations

[1]Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. J Med Chem. 2012 Dec 27;55 (24) :10844-62.