CBX2, GST-tag Recombinant
Human chromobox homolog 2 (CBX2), also known as SRXY5 and cell division cycle associated 6 (CDCA6), GenBank Accession No. NM_005189, a.a. 2-90, with N-terminal GST-tag, MW=37.3 kDa, expressed in anE. colicell expression system.
Product Specifications
Background
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys119, rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
UniProt
Q14781
Tag
N-terminal GST-tag
Applications
Useful for protein binding assays, screening inhibitors, and selectivity profiling.
Purity
≥ 79%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
≥ 6 months at -80°C
Calculated Molecular Weight
37.3 kDa
Formulation
40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, 20% glycerol.
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