CBX1, GST-tag Recombinant
Human chromobox homolog 1 (CBX1), also known as p25beta, M31, HP1-beta, and MOD1, GenBank Accession No. NM_006807, a.a. 2-185 (end), with N-terminal GST-tag, MW=48.1 kDa, expressed in anE. colicell expression system.
Product Specifications
Background
Component of heterochromatin. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Recognizes and binds histone H3 tails methylated at Lys9, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
UniProt
P83916
Tag
N-terminal GST-tag
Applications
Useful for protein binding assays, screening inhibitors, and selectivity profiling.
Purity
≥ 78%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
≥ 6 months at -80°C
Calculated Molecular Weight
48.1 kDa
Formulation
40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, and 20% glycerol.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
