c-Met-IN-23
Product Specifications
UNSPSC Description
c-Met-IN-23 (Compound 12g) is a c-Met inhibitor (IC50 = 0.052 μM for c-Met). c-Met-IN-23 also inhibits MDR1 and MRP1/2 pumps in the cancerous HepG2 and BxPC3 cells. c-Met-IN-23 is an anticancer agent[1].
Target Antigen
c-Met/HGFR; P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-in-23.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C2=NN3C(N=C2)=NN=C3NCC4=CC=NC=C4)C=C1
Molecular Weight
319.32
References & Citations
[1]Khatir ZZ, et al. 4-{3-[(Pyridin-4-ylmethyl)amino]-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl}phenol: An improved anticancer agent in hepatocellular carcinoma and a selective MDR1/MRP modulator. Arch Pharm (Weinheim). 2024 Mar 5:e2300704.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161353/c-Met-IN-23-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161353/
Clinical Information
No Development Reported
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