C-Met-IN-23

C-Met-IN-23 (Compound 12g) is a c-Met inhibitor (IC50 = 0.052 μM for c-Met) . c-Met-IN-23 also inhibits MDR1 and MRP1/2 pumps in the cancerous HepG2 and BxPC3 cells. c-Met-IN-23 is an anticancer agent[1].

Product Specifications

UNSPSC

12352005

Target

C-Met/HGFR; P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/c-met-in-23.html

Solubility

10 mM in DMSO

Smiles

OC1=CC=C(C2=NN3C(N=C2)=NN=C3NCC4=CC=NC=C4)C=C1

Molecular Formula

C16H13N7O

Molecular Weight

319.32

References & Citations

[1]Khatir ZZ, et al. 4-{3-[ (Pyridin-4-ylmethyl) amino]-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl}phenol: An improved anticancer agent in hepatocellular carcinoma and a selective MDR1/MRP modulator. Arch Pharm (Weinheim) . 2024 Mar 5:e2300704.