Ingenol Mebutate (Standard)

Ingenol Mebutate (Standard) is the analytical standard of Ingenol Mebutate. This product is intended for research and analytical applications. Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

Product Specifications

CAS Number

[75567-37-2]

Product Name Alternative

Ingenol 3-angelate (Standard) ; PEP005 (Standard)

UNSPSC

12352211

Target

PKC; Reference Standards

Type

Reference Standards

Related Pathways

Epigenetics; Others; TGF-beta/Smad

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ingenol-mebutate-standard.html

Smiles

C/C=C(C)\C(O[C@H]1C(C)=C[C@]23[C@]1(O)[C@H](O)C(CO)=C[C@@](C3=O)([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]2C)=O

Molecular Formula

C25H34O6

Molecular Weight

430.53

References & Citations

[1]Kedei N, et al. Characterization of the interaction of ingenol 3-angelate with protein kinase C. Cancer Res. 2004 May 1;64 (9) :3243-55.|[2]Hampson P, et al. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood. 2005 Aug 15;106 (4) :1362-8.|[3]Ghoul A, et al. Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. Cancer Res. 2009 May 15;69 (10) :4260-9.