Ritonavir-d8
Ritonavir-d8 is deuterated labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
Product Specifications
Product Name Alternative
ABT 538-d8; RTV-d8
UNSPSC
12352005
Target
Apoptosis; HIV; HIV Protease; Isotope-Labeled Compounds; SARS-CoV
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Others
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Solubility
10 mM in DMSO
Smiles
O[C@@H](C[C@H](CC1=CC=CC=C1)NC([C@@](NC(N(CC2=CSC(C(C)C)=N2)C)=O)([2H])C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])=O)[C@H](CC3=CC=CC=C3)NC(OCC4=CN=CS4)=O
Molecular Formula
C37H40D8N6O5S2
Molecular Weight
728.99
References & Citations
[1]Eagling VA, et al. Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir. Br J Clin Pharmacol. 1997 Aug;44 (2) :190-4.|[2]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6 (1) :212.|[3]Kumar GN, et al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug;27 (8) :902-8.|[4]Kumar GN, et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther. 1996 Apr;277 (1) :423-31.|[5]Drewe J, et al. HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833. Biochem Pharmacol. 1999 May 15;57 (10) :1147-52.|[6]Weichold FF, et al. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol. 1999 Sep-Oct;2 (5) :261-9.|[7]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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