Methylnitronitrosoguanidine

Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen[1][2]. 50% water content, specifications are based on dry weight.

Product Specifications

CAS Number

[70-25-7]

Product Name Alternative

MNNG

UNSPSC

12352211

Hazard Statement

H315, H319, H332, H350, H411

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/methylnitronitrosoguanidine.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N=C(N[N+]([O-])=O)N(C)N=O

Molecular Formula

C2H5N5O3

Molecular Weight

147.09

Precautions

H315, H319, H332, H350, H411

References & Citations

[1]Slapikoff SA, et, al. Comparison of toxicity and mutagenicity of methylnitrosourea, methylnitronitrosoguanidine and ICR-191 among human lymphoblast lines. Mutat Res. 1980 May;70 (3) :365-71.|[2]Zhang L, Jia B, et, al. Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine. Environ Toxicol. 2022 May;37 (5) :1222-1230.|[3]Bignami M, et al. Temporal dissociation in the exposure times required for maximal induction of cytotoxicity, mutation, and transformation by N-methyl-N'-nitro-N-nitrosoguanidine in the BALB/3T3 ClA31-1-1 cell line. Cancer Res. 1984 Jun;44 (6) :2452-7.|[4]Wen JX, et al. Therapeutic effects and potential mechanism of dehydroevodiamine on N-methyl-N'-nitro-N-nitrosoguanidine-induced chronic atrophic gastritis. Phytomedicine. 2021 Oct;91:153619.|[5]Ghoneum MH, et al. Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats. Int J Biol Sci. 2015 Jan 28;11 (3) :295-303.