R (+) -8-OH-DPAT (hydrobromide)

R (+) -8-OH-DPAT ((R) -8-Hydroxy-2-dipropylaminotetralin) hydrobromide is a potent 5-HT1A agonist. R (+) -8-OH-DPAT potentiates SUL (HY-B1059) -induced dopamine (DA) release in the medial prefrontal cortex (mPFC) [1].

Product Specifications

CAS Number

[78095-19-9]

Product Name Alternative

(R) -8-Hydroxy-2-dipropylaminotetralin (hydrobromide)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-plus-8-oh-dpat-hydrobromide.html

Purity

99.30

Smiles

OC1=C2C[C@H](N(CCC)CCC)CCC2=CC=C1.Br

Molecular Formula

C16H26BrNO

Molecular Weight

328.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Ichikawa J, et al. R (+) -8-OH-DPAT, a serotonin (1A) receptor agonist, potentiated S (-) -sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. J Pharmacol Exp Ther. 1999 Dec;291 (3) :1227-32.