SAFit1
SAFit1 is a FK506 binding protein 51 (FKBP51) -specific inhibitor with a Ki of 4±0.3 nM[1][2].
Product Specifications
CAS Number
1643125-32-9
UNSPSC
12352005
Target
FKBP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
Neuroscience-Neurodegeneration
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SAFit1.html
Purity
99.49
Solubility
DMSO : ≥ 300 mg/mL
Smiles
O=C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(OCC(O)=O)=CC=C2)CCC3=CC(OC)=C(OC)C=C3)=O)[C@@H](C4CCCCC4)C5=CC(OC)=C(OC)C(OC)=C5
Molecular Formula
C42H53NO11
Molecular Weight
747.87
References & Citations
[1]Gaali S, et al. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat Chem Biol. 2015 Jan;11 (1) :33-7.|[2]Sidibeh CO, et al. FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes. Endocrine. 2018 Oct;62 (1) :116-128.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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