ADWX 1 (TFA)

ADWX 1 TFA is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC50 value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 TFA ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 TFA can be used to study T cell-mediated autoimmune diseases[1][2].

Product Specifications

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/adwx-1-tfa.html

Purity

98.37

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C([C@@H](N)C(C)C)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]2CCCCN)=O)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CCSC)=O)=O)C)=O)CC(O)=O)=O)CCCCN)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N5[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCC5)=O)[C@@H](C)O)=O)=O)CCC1)=O)CCCCN)=O)CC(C)C)=O)CSSC[C@H](NC6=O)C(N[C@H]4CC7=CNC=N7)=O)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CO)=O)CC8=CNC=N8)=O)CCCCN)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]6CCCCN)=O)=O)CC(N)=O)=O)[C@@H](C)O)=O)=O)CCCCN)=O)C(C)C)=O)CC(N)=O)=O)[C@H](CC)C)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C169H281N57O46S7.xC2HF3O2

Molecular Weight

4071.85 (free base)

References & Citations

[1]Han S, et al. Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem. 2008 Jul 4;283 (27) :19058-65.|[2]Li Z, et al. Selective inhibition of CCR7 (-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model. J Biol Chem. 2012 Aug 24;287 (35) :29479-94.