ARS-1620
ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
Product Specifications
CAS Number
[1698055-85-4]
UNSPSC
12352005
Hazard Statement
H302
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ARS-1620.html
Concentration
10mM
Purity
99.59
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 11 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
C=CC(N1CCN(C2=C3C=C(Cl)[C@]([C@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1)=O.[S]
Molecular Formula
C21H17ClF2N4O2
Molecular Weight
430.84
Precautions
H302
References & Citations
[1]Janes MR, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018 Jan 25;172 (3) :578-589.e17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
Curated Selection
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