Recombinant SARS-CoV-2 NSP12

The replication of Coronavirus is operated by multiple non-structural proteins (nsps). The viral genomic RNA is translated from two open reading frames (ORFs), ORF1a and ORF1b. The encoded replicase polyproteins, pp1a and pp1ab, are further processed to produce nsps. NSP12 encoded by ORF1b has the viral RNA-dependent RNA polymerase (RdRp) motif. It is the catalytic core of the RNA replicase.