PF-07957472

PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC50 = 13.9 nM) . PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model[1].

Product Specifications

CAS Number

[3041047-51-9]

UNSPSC

12352005

Target

SARS-CoV; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pf-07957472.html

Purity

99.13

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC(N2CCN(CC2)C)=CC=C1C)NC3(CC3)C4=C5C=CC=CC5=NC(C6=CN(C)N=C6)=C4

Molecular Formula

C29H32N6O

Molecular Weight

480.60

References & Citations

[1]Garnsey MR, et al. Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model. Sci Adv. 2024 Aug 30;10 (35) :eado4288.