PF-07957472
PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC50 = 13.9 nM) . PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model[1].
Product Specifications
CAS Number
[3041047-51-9]
UNSPSC
12352005
Target
SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pf-07957472.html
Purity
99.13
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC(N2CCN(CC2)C)=CC=C1C)NC3(CC3)C4=C5C=CC=CC5=NC(C6=CN(C)N=C6)=C4
Molecular Formula
C29H32N6O
Molecular Weight
480.60
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169092/PF-07957472-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169092/PF-07957472-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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