JFD00244
JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against SARS-CoV-2[1][2].
Product Specifications
CAS Number
96969-83-4
UNSPSC
12352005
Hazard Statement
H410
Target
SARS-CoV; Sirtuin
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jfd00244.html
Purity
99.40
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C=CC=C2)C(C3=C(NCCC4=CC=C(O)C=C4)C=CC(NCCC5=CC=C(O)C=C5)=C13)=O
Molecular Formula
C30H26N2O4
Molecular Weight
478.54
Precautions
H410
References & Citations
[1]Ciarlo C, A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. Elife. 2017 Aug 23;6. pii: e29145.|[2]Shankar U, et al. Potential Drugs Targeting Nsp16 Protein May Corroborates a Promising Approach to Combat SARSCoV-2 Virus. ChemRxiv. Cambridge: Cambridge Open Engage; 2020; This content is a preprint and has not been peer-reviewed. |[3]Kim Dae Jung, et al. Pharmaceutical composition for preventing and treating prostate cancer: World Intellectual Property Organization, WO2014065537[P]. 2014-05-01.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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