(R)-(4-NH2)-Exatecan
Product Specifications
UNSPSC Description
(R)-(4-NH2)-Exatecan is the R enantiomer of (4-NH2)-Exatecan (Compound A). (R)-(4-NH2)-Exatecan, a topoisomerase inhibitor, is a derivative of Exatecan. (R)-(4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
Target Antigen
ADC Cytotoxin; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-4-nh2-exatecan.html
Smiles
NC1=CC=C2C3=C1CCCC3=C4CN5C(C4=N2)=CC([C@@](O)6CC)=C(C5=O)COC6=O
Molecular Weight
403.43
References & Citations
[1]Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145397A/R-4-NH2-Exatecan-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145397A/
Clinical Information
No Development Reported
Curated Selection
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