KRAS G12D inhibitor 23

KRAS G12D inhibitor 23 (compound 46-3) is a potent inhibitor of KRAS G12D, with the IC50 of 0.007 μM. KRAS G12D inhibitor 23 plays an important role in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kras-g12d-inhibitor-23.html

Smiles

FC1=CC2=C(N3C[C@H]4N[C@H](CC4)C3)N=C(OC[C@@]5(C)[C@H](CCN(C5)C)C(F)F)N=C2C(F)=C1C6=CC(O)=CC7=C6C(C#C)=C(F)C=C7

Molecular Formula

C35H34F5N5O2

Molecular Weight

651.67

References & Citations

[1]Tyligand Bioscience (Shanghai) Limited. Quinazoline compounds as KRAS inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. World Intellectual Property Organization, WO2024067714 A1 2024-04-04