KRAS G12D inhibitor 23
KRAS G12D inhibitor 23 (compound 46-3) is a potent inhibitor of KRAS G12D, with the IC50 of 0.007 μM. KRAS G12D inhibitor 23 plays an important role in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12d-inhibitor-23.html
Smiles
FC1=CC2=C(N3C[C@H]4N[C@H](CC4)C3)N=C(OC[C@@]5(C)[C@H](CCN(C5)C)C(F)F)N=C2C(F)=C1C6=CC(O)=CC7=C6C(C#C)=C(F)C=C7
Molecular Formula
C35H34F5N5O2
Molecular Weight
651.67
References & Citations
[1]Tyligand Bioscience (Shanghai) Limited. Quinazoline compounds as KRAS inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. World Intellectual Property Organization, WO2024067714 A1 2024-04-04
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
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