Human TBK1 Active GST Tagged

<strong>Human TBK1 Active GST Tagged</strong>_x000D_ <strong>Catalog number:</strong> B2016566_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> ~105 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −80°C_x000D_ <strong>Keywords:</strong> FLJ11330, NAK, T2K_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong> _x000D_ 1: Yu H, Yu W, Luo SS, Yang YJ, Liu FT, Zhang Y, Chen Y, Sun YM, Wu JJ. Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review Mol Genet Genomic Med. 2019 Mar;7(3):e547. _x000D_ 2: Yu N, Xu X, Qi G, Liu D, Chen X, Ran X, Jiang Z, Li Y, Mao H, Hu C. Ctenopharyngodon idella TBK1 activates innate immune response via IRF7 Fish Shellfish Immunol. 2018 Sep;80:521-527. _x000D_ 3: Lv Y, Deng H, Liu Y, Chang K, Du H, Zhou P, Mao H, Hu C. The tyrosine kinase SRC of grass carp (Ctenopharyngodon idellus) up-regulates the expression of IFN I by activating TANK binding kinase 1 Dev Comp Immunol. 2021 Jan;114:103834. _x000D_ 4: Kaukinen P, Sillanpää M, Nousiainen L, Melén K, Julkunen I. Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions J Med Virol. 2013 Jan;85(1):71-82. _x000D_ 5: Runde AP, Mack R, S J PB, Zhang J. The role of TBK1 in cancer pathogenesis and anticancer immunity J Exp Clin Cancer Res. 2022 Apr 9;41(1):135. _x000D_ 6: Zhang C, Shang G, Gui X, Zhang X, Bai XC, Chen ZJ. Structural basis of STING binding with and phosphorylation by TBK1 Nature. 2019 Mar;567(7748):394-398. _x000D_ 7: Zhang Q, Liu S, Zhang CS, Wu Q, Yu X, Zhou R, Meng F, Wang A, Zhang F, Chen S, Wang X, Li L, Huang J, Huang YW, Zou J, Qin J, Liang T, Feng XH, Lin SC, Xu P. AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity Mol Cell. 2022 Dec 1;82(23):4519-4536.e7. _x000D_ 8: Banoth B, Cassel SL. Mitochondria in innate immune signaling Transl Res. 2018 Dec;202:52-68. _x000D_ 9: Lafont E, Draber P, Rieser E, Reichert M, Kupka S, de Miguel D, Draberova H, von Mässenhausen A, Bhamra A, Henderson S, Wojdyla K, Chalk A, Surinova S, Linkermann A, Walczak H. TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation Nat Cell Biol. 2018 Dec;20(12):1389-1399. _x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/36652744">10: Wan S, Cui Z, Wu L, Zhang F, Liu T, Hu J, Tian J, Yu B, Liu F, Kou J, Li F. Ginsenoside Rd promotes omentin secretion in adipose through TBK1-AMPK to improve mitochondrial biogenesis via WNT5A/Ca(2+) pathways in heart failure Redox Biol. 2023 Apr;60:102610. </a>_x000D_ <br><strong>Products Related to Human TBK1 Active GST Tagged can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>