5α-Androstan-3β-ol

5α-Androstan-3β-ol (Androstan), a saturated sterol, is a CAR (constitutive androstane receptor) inverse agonist ligand. 5α-Androstan-3β-ol (Androstan) increases the AmB-channel conductance in a concentration dependent manner[1][2].

Product Specifications

CAS Number

[1224-92-6]

Product Name Alternative

3β-Hydroxy-5α-androstane

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5α-androstan-3β-ol.html

Purity

98.00

Smiles

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(CCC4)C

Molecular Formula

C19H32O

Molecular Weight

276.46

Precautions

H302, H315, H319, H335

References & Citations

[1]I Tzameli, et al. T he xenobiotic compound 1,4-bis[2- (3,5-dichloropyridyloxy) ]benzene is an agonist ligand for the nuclear receptor CAR. Mol Cell Biol. 2000 May;20 (9) :2951-8.|[2]Olga S Ostroumova, et al. Probing amphotericin B single channel activity by membrane dipole modifiers. PLoS One. 2012;7 (1) :e30261.