1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone

<strong>1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone Dihydrochloride</strong>_x000D_ <strong>Catalog number:</strong> B2010255_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 5 mg_x000D_ <strong>pH:</strong> n/a_x000D_ <strong>Supplied as:</strong> Reconstitute before use_x000D_ <strong>Appearance:</strong> Solid_x000D_ <strong>Applications:</strong> high purity effective irreversible inhibitor of uPA, Factor Xa, and urokinase (does not inhibit tPA). The presence of a fluorofore conviniently allows the monitoring of molecular interactions._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> 1,5-DNS-GGACK, 2HCl_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Lyon ME, Drobot DW, Harding SR, Lyon AW. Evaluation of the thrombin inhibitor_x000D_ D-phenylalanyl-L-prolyl-L-arginine chloromethylketone (PPACK) with the factor Xa_x000D_ inhibitor 1,5-dansyl-L-glutamyl-L-glycyl-L-arginine chloromethylketone (GGACK)_x000D_ as anticoagulants for critical care clinical chemistry specimens. Clin Chim_x000D_ Acta. 1999 Feb;280(1-2):91-9._x000D_ _x000D_ 2: Kemball-Cook G, Johnson DJ, Tuddenham EG, Harlos K. Crystal structure of_x000D_ active site-inhibited human coagulation factor VIIa (des-Gla). J Struct Biol._x000D_ 1999 Oct;127(3):213-23._x000D_ _x000D_ 3: Hohsaka T, Muranaka N, Komiyama C, Matsui K, Takaura S, Abe R, Murakami H,_x000D_ Sisido M. Position-specific incorporation of dansylated non-natural amino acids_x000D_ into streptavidin by using a four-base codon. FEBS Lett. 2004 Feb_x000D_ 27;560(1-3):173-7._x000D_ _x000D_ 4: Norstrøm EA, Tran S, Steen M, Dahlbäck B. Effects of factor Xa and protein S_x000D_ on the individual activated protein C-mediated cleavages of coagulation factor_x000D_ Va. J Biol Chem. 2006 Oct 20;281(42):31486-94._x000D_ _x000D_ 5: Marrakchi S, Maibach HI. Functional map and age-related differences in the_x000D_ human face: nonimmunologic contact urticaria induced by hexyl nicotinate._x000D_ Contact Dermatitis. 2006 Jul;55(1):15-9._x000D_ _x000D_ 6: Hu CK, Kohnert U, Wilhelm O, Fischer S, Llinás M. Tissue-type plasminogen_x000D_ activator domain-deletion mutant BM 06.022: modular stability, inhibitor_x000D_ binding, and activation cleavage. Biochemistry. 1994 Oct 4;33(39):11760-6._x000D_ _x000D_ 7: Burtnick LD, Bhangu K. Interaction of actin with dansyl-tropomyosin. FEBS_x000D_ Lett. 1986 Mar 31;198(2):307-10._x000D_ _x000D_ 8: Johannesson A, Hammar H. Measurement of the horny layer turnover after_x000D_ staining with dansyl chloride: description of a new method. Acta Derm Venereol._x000D_ 1978;58(1):76-9._x000D_ _x000D_ 9: Camerer E, Rottingen JA, Iversen JG, Prydz H. Coagulation factors VII and X_x000D_ induce Ca2+ oscillations in Madin-Darby canine kidney cells only when_x000D_ proteolytically active. J Biol Chem. 1996 Nov 15;271(46):29034-42._x000D_ _x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/10196120/">Johnson DJ, Nugent PG, Tuddenham EG, Harlos K, Kemball-Cook G._x000D_ Crystallization and preliminary X-ray analysis of active site-inhibited human_x000D_ coagulation factor VIIa (des-Gla). J Struct Biol. 1999 Mar;125(1):90-3.</a>_x000D_ _x000D_ <strong>Products Related to 1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone Dihydrochloride </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>