6,8-Diprenylorobol
Product Specifications
UNSPSC Description
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS[1][2].
Target Antigen
Akt; Apoptosis; Bcl-2 Family; Caspase; ERK; JNK; p38 MAPK; Reactive Oxygen Species
Type
Natural Products
Related Pathways
Apoptosis;Immunology/Inflammation;MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6-8-diprenylorobol.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C2=CC=C(O)C(O)=C2)=COC3=C(C/C=C(C)\C)C(O)=C(C/C=C(C)\C)C(O)=C13
Molecular Weight
422.47
References & Citations
[1]Choi YJ, et, al. 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53. Environ Toxicol. 2021 May;36(5):914-925.|[2]Tuan Anh HL, et, al. Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation. J Asian Nat Prod Res. 2017 May;19(5):510-518.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N2693/6-8-Diprenylorobol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N2693/
Clinical Information
No Development Reported
CAS Number
66777-70-6
Available Sizes
Curated Selection
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