6,8-Diprenylorobol

6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS[1][2].

Product Specifications

CAS Number

[66777-70-6]

UNSPSC

12352005

Target

Akt; Apoptosis; Bcl-2 Family; Caspase; ERK; JNK; p38 MAPK; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/6-8-diprenylorobol.html

Purity

98.40

Solubility

10 mM in DMSO

Smiles

O=C1C(C2=CC=C(O)C(O)=C2)=COC3=C(C/C=C(C)\C)C(O)=C(C/C=C(C)\C)C(O)=C13

Molecular Formula

C25H26O6

Molecular Weight

422.47

References & Citations

[1]Choi YJ, et, al. 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53. Environ Toxicol. 2021 May;36 (5) :914-925.|[2]Tuan Anh HL, et, al. Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation. J Asian Nat Prod Res. 2017 May;19 (5) :510-518.