Aberrant tau ligand 1

Aberrant tau ligand 1 is a ligand for tau proteins with abnormal forms. Aberrant tau ligand 1 can be used for synthesis of PROTAC aberrant Tau degrader QC-01-175 (HY-134850) [1].

Product Specifications

CAS Number

[1892461-96-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aberrant-tau-ligand-1.html

Purity

99.33

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)CCC1=CC2=C(C=C1)C(C=NC=C3)=C3N2

Molecular Formula

C14H12N2O2

Molecular Weight

240.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Silva MC, et al., Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 Mar 25;8:e45457.