Vosilasarm
Vosilasarm (RAD140) is a potent, orally active, nonsteroidal selective androgen receptor modulator (SARM) with a Ki of 7 nM. Vosilasarm shows good selectivity over other steroid hormone nuclear receptors[1].
Product Specifications
CAS Number
1182367-47-0
Product Name Alternative
RAD140; EP0062
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Endocrinology; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/RAD140.html
Purity
99.80
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC1=C(C)C(N[C@]([H])([C@@]([H])(O)C)C2=NN=C(O2)C3=CC=C(C#N)C=C3)=CC=C1C#N
Molecular Formula
C20H16ClN5O2
Molecular Weight
393.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Miller CP, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2010 Dec 2;2 (2) :124-129.|[2]Jayaraman A, et al. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014 Apr;155 (4) :1398-1406.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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