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Hydroxyebastine

Hydroxyebastine is an Ebastine (HY-B0674) (a histamine H1-receptor antagonist) metabolite. Hydroxyebastine is metabolized to Carebastine (HY-121356) by CYP2J2 and CYP3A4[1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hydroxyebastine.html

Smiles

O=C(CCCN1CCC(CC1)OC(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=C(C(C)(CO)C)C=C4

Molecular Formula

C32H39NO3

Molecular Weight

485.66

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Liu KH, et al. Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34 (11) :1793-7.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-122508/Hydroxyebastine-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-122508/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[210686-41-2]

Available Sizes

Curated Selection

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