D-Dopa

D-Dopa (3-Hydroxy-D-tyrosine) is a potent, orally active, non-competitive and allosteric inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa elevates brain dopamine and produce turning behavior in rats. D-Dopa inhibit severe fever with thrombocytopenia syndrome (SFTS) virus infection. D-Dopa can be used for neurological disease and virus infection research[1][2][3].

Product Specifications

CAS Number

[5796-17-8]

Product Name Alternative

3-Hydroxy-D-tyrosine

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Carboxypeptidase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-dopa.html

Purity

97.0

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

OC([C@H](N)CC1=CC(O)=C(C=C1)O)=O

Molecular Formula

C9H11NO4

Molecular Weight

197.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Gori SS, et al., D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II. Pharmaceutics. 2022 Sep 23;14 (10) :2018. |[2]Karoum F, et al. D-dopa and L-dopa similarly elevate brain dopamine and produce turning behavior in rats. Brain Res. 1988 Feb 2;440 (1) :190-4.|[3]Ogawa M, et al. L-DOPA, a treatment for Parkinson's disease, and its enantiomer D-DOPA inhibit severe fever with thrombocytopenia syndrome virus infection in vitro. J Infect Chemother. 2022 Mar;28 (3) :373-376.