CSI86
Product Specifications
UNSPSC Description
CSI86 is a MYC-targeting PROTAC degrader with antiproliferative activity (IC50: 13-18 μM)[1]. CSI86 is composed of MYC inhibitor (red part) CSI118 TFA (HY-169379), E3 ligase ligand (blue part) VH032 (HY-120217), and PROTAC linker (black part) Succinic anhydride (HY-79369). The conjugate composed of E3 ligase ligand and linker is (S,R,S)-CO-C2-acid (HY-131866).
Target Antigen
c-Myc; PROTACs
Type
Reference compound
Related Pathways
Apoptosis;PROTAC
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/csi86.html
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCC(NCCCOC4=C(C(O)=C(C=C4)C5=CC(C(F)(F)F)=NN5C)C6=CC(C(F)(F)F)=CC(C(F)(F)F)=C6)=O)=O)=O)O)=O
Molecular Weight
1040.00
References & Citations
[1]Siokatas C, et al. Developing MYC Degraders Bearing the Von Hippel–Lindau Ligand to Target the “Undruggable” MYC[J]. ACS Pharmacology & Translational Science, 2024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169378/CSI86-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169378/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7169902 Inquire
Rabbit anti-Escherichia coli O139:H28 (strain E24377A/ETEC) argS Polyclonal Antibody
Ask
View Details