Vaborbactam
Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor.
Product Specifications
CAS Number
[1360457-46-0]
Product Name Alternative
RPX7009
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Vaborbactam.html
Purity
99.85
Solubility
H2O : 5.26 mg/mL (ultrasonic)
Smiles
O=C(O)C[C@@H]1CC[C@H](NC(CC2=CC=CS2)=O)B(O)O1
Molecular Formula
C12H16BNO5S
Molecular Weight
297.14
Precautions
H302, H312, H332
References & Citations
[1]Hecker SJ, et al. Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. J Med Chem. 2015 May 14;58 (9) :3682-92.|[2]Castanheira M, et al. Effect of the β-Lactamase Inhibitor Vaborbactam Combined with SM 7338 against Serine Carbapenemase-Producing Enterobacteriaceae. Antimicrob Agents Chemother. 2016 Aug 22;60 (9) :5454-8.|[3]Wong D, et al. Novel Beta-Lactamase Inhibitors: Unlocking Their Potential in Therapy.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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