Promestriene

Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed[1][2].

Product Specifications

CAS Number

[39219-28-8]

UNSPSC

12352005

Hazard Statement

H302-H312-H332-H360

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/promestriene.html

Purity

99.91

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@@H](OC)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(OCCC)=C4)[C@@]3([H])CC2

Molecular Formula

C22H32O2

Molecular Weight

328.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Isabel Santos, et al. Urogenital Disorders Associated With Oestrogen Deficiency: The Role of Promestriene as Topical Oestrogen Therapy. Gynecol Endocrinol. 2010 Sep;26 (9) :644-51.|[2]Lino Del Pup, et al. Promestriene, a Specific Topic Estrogen. Review of 40 Years of Vaginal Atrophy Treatment: Is It Safe Even in Cancer Patients. Anticancer Drugs. 2013 Nov;24 (10) :989-98.|[3]AJO Almodovar, et al. Abstract P5-05-07: Promestriene effects on estrogen-sensitive breast cancer cell proliferation in vitro. Cancer Res 2013;73 (24 Suppl) : Abstract nr P5-05-07.