Emivirine

Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity[1][2].

Product Specifications

CAS Number

[149950-60-7]

Product Name Alternative

MKC-442

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/emivirine.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC(C(C(C)C)=C(CC2=CC=CC=C2)N1COCC)=O

Molecular Formula

C17H22N2O3

Molecular Weight

302.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Panita Decha, et al. Theoretical studies on the molecular basis of HIV-1RT/NNRTIs interactions. J Enzyme Inhib Med Chem. 2011 Feb;26 (1) :29-36.|[2]G M Szczech, et al. Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2000 Jan;44 (1) :123-30.