J1075
J1075 is a selective Schistosoma mansoni HDAC8 inhibitor (with decreased affinity for human HDAC8) . J1075 can induce apoptosis (Apoptosis) and death in schistosome cells. J1075 holds research value in the field of anti-parasitic agents[1].
Product Specifications
CAS Number
383892-69-1
UNSPSC
12352005
Target
HDAC; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/j1075.html
Smiles
O=C(NO)C1=C(C2=CC=CC=C2S1)Cl
Molecular Formula
C9H6ClNO2S
Molecular Weight
227.67
References & Citations
[1]Marek M, et al. Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni. PLoS Pathog. 2013;9 (9) :e1003645.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC8
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