3-Demethylcolchicine

3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema[1][2].

Product Specifications

CAS Number

[7336-33-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/3-demethylcolchicine.html

Purity

99.03

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N[C@H](C1=C2)CCC3=CC(O)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)=O

Molecular Formula

C21H23NO6

Molecular Weight

385.41

Precautions

H302, H315, H319

References & Citations

[1]Modriansky M, et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?. Toxicology. 2002;177 (1) :105-117.|[2]Sugio K, et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 1987;40 (1) :35-39.