NF-κB-IN-15
Product Specifications
UNSPSC Description
NF-κB-IN-15 (compound 14r) is a potent NF-κB inhibitor. NF-κB-IN-15 decreases the NO levels and inhibits the release of IL-6, TNF-α, and IL-1β in LPS (HY-D1056) -induced cells. NF-κB-IN-15 inhibits LPS-induced phosphorylation of p65 and degradation of IκBα. NF-κB-IN-15 shows anti-inflammatory activity has the potential for the research of acute lung injury (ALI)[1].
Target Antigen
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nf-κb-in-15.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C)C=CC=C1N2CCN(C([C@H](CC3=CC(OC)=C(O)C(OC)=C3)[C@@H](C(N4CCN(C5=CC=CC(C)=C5C)CC4)=O)CC6=CC(OC)=C(O)C(OC)=C6)=O)CC2
Molecular Weight
794.97
References & Citations
[1]Zhang J, et al. Total synthesis and structural modification of the dibenzylbutane lignan LCA as a potent anti-inflammatory agent against LPS-induced acute lung injury. Eur J Med Chem. 2024 Feb 20;268:116272.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162316/NF-κB-IN-15-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162316/
Clinical Information
No Development Reported
Curated Selection
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