Rhesus macaque GITR / TNFRSF18 Protein, Fc Tag

Rhesus macaque GITR, Fc Tag (GIR-C5255) is expressed from human 293 cells (HEK293) . It contains AA Gln 26 - Glu 161 (Accession # F7DDV8) .

Product Specifications

Background

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.3 kDa. The protein migrates as 48 kDa under reducing (R) condition, and 85 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Accession Number

F7DDV8

Expression Region

Gln 26 - Glu 161

Host

HEK293

Target

GITR

Conjugation

Unconjugated

Tag

C-Fc

Source

Rhesus macaque

Stability

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.