IL23A rabbit pAb

Developmental stage: Expressed by newborns dendritic cells. function: Associates with IL12B to form the IL-23 interleukin, an heterodimeric Cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. induction: Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors. similarity: Belongs to the IL-6 superfamily. subcellular location: Secreted upon association with IL12B. subunit: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. tissue specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).